Transdermal delivery of multifunctional CaO<sub>2</sub>@Mn-PDA nanoformulations by microneedles for NIR-induced synergistic therapy against skin melanoma
Liming Ruan, Song Gao, Xueya Zhang, Tianqi Liu, Yanfang Sun, Junlan Zhu, Zhiyong Zeng, Guohua Jiang
Abstract
The CaO 2 @Mn-PDA nanoformulations, integrated with photothermal conversion of Mn-PDA, CDT of doped Mn ions, and relieve hypoxia in TME of CaO 2 , were developed for NIR-induced synergistic therapy against melanoma by microneedles transdermal delivery.
Topics & Concepts
Photothermal therapyTransdermalMelanomaChemistryCancer researchHypoxia (environmental)NanotechnologyMaterials sciencePharmacologyMedicineOxygenOrganic chemistryNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseCancer, Stress, Anesthesia, and Immune Response