Synthesis, biochemical and computational evaluations of novel bis-acylhydrazones of 2,2′-(1,1′-biphenyl)-4,4′-diylbis(oxy))di(acetohydrazide) as dual cholinesterase inhibitors
Muhammad Ibrahim, Sobia Ahsan Halim, Abdul Latif, Manzoor Ahmad, Sajid Ali, Samee Ullah, Asaad Khalid, Ashraf N. Abdalla, Ajmal Khan, Ahmed Al‐Harrasi, Mumtaz Ali, Mumtaz Ali
Topics & Concepts
ChemistryButyrylcholinesteraseAcetylcholinesteraseCholinesteraseIC50StereochemistryAchéHydrazine (antidepressant)EnzymeMedicinal chemistryIn vitroCombinatorial chemistryOrganic chemistryBiochemistryPharmacologyMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsEnzyme function and inhibition