Litcius/Paper detail

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

Xin Gu, Patrick Jouandin, Pranav V. Lalgudi, Rich Binari, Max L. Valenstein, Michael A. Reid, Annamarie E. Allen, Nolan Kamitaki, Jason W. Locasale, Norbert Perrimon, David M. Sabatini

2022Nature59 citationsDOIOpen Access PDF

Topics & Concepts

LeucinemTORC1Gene knockdownAmino acidBiologyCell biologyBiochemistryAutophagyGeneSignal transductionPI3K/AKT/mTOR pathwayApoptosisNeurobiology and Insect Physiology ResearchPlant biochemistry and biosynthesisPI3K/AKT/mTOR signaling in cancer