Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina
Laurel C. Chandler, Michelle E. McClements, Imran H. Yusuf, Cristina Martínez-Fernández de la Cámara, Robert E. MacLaren, Kanmin Xue
Abstract
) elicited a significantly diminished cellular immune response (4.2-fold; p = 0.0221). However, the distribution of immune cell populations remained similar, indicating a common mechanism of AAV-induced immune activation.
Topics & Concepts
Immune systemBiologyGenetic enhancementMicrogliaImmunologyViral vectorAdeno-associated virusCD8Flow cytometryRetinalInflammationTransgenePopulationAcquired immune systemCell biologyVector (molecular biology)GeneMedicineGeneticsBiochemistryEnvironmental healthRecombinant DNARetinal Development and DisordersRetinal and Optic ConditionsVirus-based gene therapy research