Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia
Serina L. Robinson, Barbara R. Terlouw, Megan D. Smith, Sacha J. Pidot, Timothy P. Stinear, Marnix H. Medema, Lawrence P. Wackett
Abstract
to link the gene cluster to the β-lactone natural product, nocardiolactone. We anticipate that our machine learning approach will aid in functional classification of enzymes and advance natural product discovery.
Topics & Concepts
BiosynthesisEnzymeAdenylate kinaseNocardiaBiochemistryMicrobiologyChemistryBiologyGeneticsBacteriaActinomycetales infections and treatmentMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic Studies