Electrochemical phosphorylation of arenols and anilines leading to organophosphates and phosphoramidates
Zijian Zhong, Pan Xu, Aihua Zhou
Abstract
A practical phosphorylation for generating organophosphates and phosphoramidates via electrochemical dehydrogenative cross-coupling of P(O)H compounds with arenols and anilines is disclosed. This method involves using inorganic iodide salts as both redox catalysts and electrolytes in an undivided cell without the addition of oxidants or bases. A preliminary mechanistic study suggests that radicals are not involved in this process. This method is green and eco-friendly and has good functional group tolerance, high yields and broad substrate scope, with the potential for practical synthesis.
Topics & Concepts
ElectrochemistryPhosphorylationSubstrate (aquarium)ChemistryBase (topology)Scope (computer science)Combinatorial chemistryBiochemistryBiologyComputer scienceMathematicsPhysical chemistryMathematical analysisEcologyProgramming languageElectrodeAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques