Design, synthesis and pharmacological evaluation of new PARP1 inhibitors by merging pharmacophores of olaparib and the natural product alantolactone
Muzaffar Kayumov, Jia Li, Azizbek Pardaev, Shanshan Song, Sharafitdin Mirzaakhmedov, Chunyong Ding, Yong-Jun Cheng, Ruihan Zhang, Xubin Bao, Ze‐Hong Miao, Jin‐Xue He, Ao Zhang
Topics & Concepts
OlaparibPARP1ChemistryPoly ADP ribose polymeraseDNA damageSynthetic lethalityNatural productApoptosisPharmacophoreCell cycleDNA repairBiochemistryEnzymeDNAPolymerasePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisDNA Repair Mechanisms