Converging on a Cure: The Roads to Predictive Immunotherapy
Genevieve Stein-O’Brien, Dung T. Le, Elizabeth M. Jaffee, Elana J. Fertig, Neeha Zaidi
Abstract
SUMMARY: Convergence science teams integrating clinical, biological, engineering, and computational expertise are inventing new forecast systems to monitor and predict evolutionary changes in tumor and immune interactions during early cancer progression and therapeutic response. The resulting methods should inform a new predictive medicine paradigm to select adaptive immunotherapeutic regimens personalized to patients' tumors at a given time during their cancer progression for durable patient response.
Topics & Concepts
ImmunotherapyPersonalized medicineCancer immunotherapyImmune systemPrecision medicineCancerMedicineComputer scienceComputational biologyBioinformaticsBiologyImmunologyInternal medicinePathologyMathematical Biology Tumor GrowthCancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomics