A stimuli-responsive, superporous and non-toxic smart hydrogel from seeds of mugwort (<i>Artemisia vulgaris</i>): stimuli responsive swelling/deswelling, intelligent drug delivery and enhanced aceclofenac bioavailability
Muhammad Farid-ul-Haq, Muhammad Ajaz Hussain, Muhammad Tahir Haseeb, Muhammad Umer Ashraf, Syed Zajif Hussain, Tahira Tabassum, Irshad Hussaın, Muhammad Sher, Syed Nasir Abbas Bukhari, Muhammad Naeem‐ul‐Hassan
Abstract
fate of the AVH tablet is monitored by X-ray during the transit through the GIT. Acute toxicity studies of AVH indicate the absence of any toxicity which reveals the safety profile of AVH. Therefore, AVH can be used for oral, topical and ophthalmic drug delivery systems. These results establish the potential of AVH as a stimuli sensitive, pH-dependent, and sustained-release biomaterial for targeted drug delivery.
Topics & Concepts
AceclofenacSwellingBioavailabilityPharmacologyChemistryDrug deliveryPharmacokineticsIn vivoDrugToxicityChromatographyMedicineBiotechnologyOrganic chemistryBiologyPathologyHydrogels: synthesis, properties, applicationsPolysaccharides and Plant Cell WallsPolysaccharides Composition and Applications