Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long‐lived individuals
Valentina Siino, Ashfaq Ali, Giulia Accardi, Anna Aiello, Mattia Emanuela Ligotti, Sergio Mosquim, Giuseppina Candore, Calogero Caruso, Fredrik Levander, Sonya Vasto
Abstract
The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.