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Frustrated Lewis Pair-Promoted Organocatalytic Transformation of Hydrosilanes into Silanols with Water Oxidant

Fuyu Xie, Sutao Zhang, Mo Yang, Jianghua He, Shuhua Li, Yuetao Zhang

2024Journal of the American Chemical Society15 citationsDOI

Abstract

Owing to their unique properties, the silanols have attracted intense attention but remain challenging to prepare from the organocatalytic oxidation of hydrosilanes using H 2 O as a green oxidant. Herein, we employ a frustrated Lewis pair (FLP) to successfully suppress the formation of undesired siloxanes and produce silanols in high to excellent yields in the presence of H 2 O. Mechanistic studies suggest that the reaction is initiated with the activation of FLP by H 2 O rather than by silanes and goes through a concerted S N 2 mechanism. More importantly, the combination of the FLP-catalyzed oxidation of hydrosilanes with B(C 6 F 5 ) 3 -catalyzed dehydrogenation enables us to realize the precise synthesis of sequence-controlled oligosiloxanes. This method exhibits a broad substrate scope and can be easily scaled up, thus exhibiting promising application potentials in the precision synthesis of silicon-containing polymer materials.

Topics & Concepts

ChemistryTransformation (genetics)Lewis acids and basesOrganocatalysisFrustrated Lewis pairOrganic chemistryCatalysisStereochemistryMedicinal chemistryEnantioselective synthesisBiochemistryGeneOrganoboron and organosilicon chemistrySulfur-Based Synthesis TechniquesChemical Synthesis and Reactions
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