Cell type-specific induction of ferroptosis to boost antitumor immunity
Jiao Liu, Jingbo Li, Rui Kang, Daolin Tang
Abstract
Traditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.
Topics & Concepts
ImmunityImmune systemSmall moleculeCancer researchImmunologyBiologyBiochemistryFerroptosis and cancer prognosisCancer Immunotherapy and Biomarkersinterferon and immune responses