Assessing the Bioactivity of Gentamicin-Preloaded Hydroxyapatite/Chitosan Composite Coating on Titanium Substrate
Milena Stevanović, Marija Djošić, Ana Janković, Katarina Nešović, Vesna Kojić, Jovica Stojanović, Svetlana Grujić, Ivana Matić Bujagić, Kyong Yop Rhee, Vesna Mišković‐Stanković
Abstract
)). Drug-release kinetics was investigated in deionized water at 37 °C by high-performance liquid chromatography coupled with mass spectrometry. Release profiles revealed the beneficial "burst-release effect" (∼21% of gentamicin released in the first 48 h) as a potentially promising solution against the biofilm formation in the initial period. When tested against human and mice fibroblast cells (MRC-5 and L929), both composite coatings showed a noncytotoxic effect (viability >85%), providing a promising basis for further medical application trials.
Topics & Concepts
ChitosanComposite numberGentamicinCoatingSubstrate (aquarium)Materials scienceTitaniumComposite materialChemical engineeringChemistryMetallurgyAntibioticsBiochemistryEngineeringGeologyOceanographyBone Tissue Engineering MaterialsPolymer Surface Interaction Studiesbiodegradable polymer synthesis and properties