Progress in the Stereoselective Synthesis Methods of Pyrrolidine-Containing Drugs and Their Precursors
Аndrey V. Smolobochkin, Almir S. Gazizov, Nurbol Appazov, Оleg G. Sinyashin, А. Р. Бурилов
Abstract
The presented review systematizes and summarizes the data on the synthesis of pyrrolidine derivatives, which are precursors for obtaining drugs. Based on the analysis of published data, the most promising directions in the synthesis of biologically active compounds containing a pyrrolidine ring are identified. Stereoselective synthesis methods are classified based on the source of the pyrrolidine ring. The first group includes methods that use a pyrrolidine ring as the starting compound. The second group combines stereoselective methods of cyclization of acyclic starting compounds, which lead to optically pure pyrrolidine derivatives.
Topics & Concepts
PyrrolidineStereoselectivityChemistryRing (chemistry)Optically activeStereochemistryCombinatorial chemistryOrganic chemistryCatalysisCarbohydrate Chemistry and SynthesisChemical Synthesis and AnalysisBiochemical and Molecular Research