High Prevalence of OXA-23 Carbapenemase-Producing <i>Proteus mirabilis</i> among Amoxicillin-Clavulanate-Resistant Isolates in France
Amélie Lombes, Rémy A. Bonnin, Frédéric Laurent, Hélène Guet-Revillet, Emmanuelle Bille, Vincent Cattoir, Marie-Sarah Fangous, Cécile Le Brun, Vincent Fihman, Frédéric Janvier, Marie-Pierre Otto, Anais Potron, Stéphane Corvec, Louise Ruffier d’Epenoux, Assaf Mizrahi, Laurent Dortet
Abstract
In this multicentric study performed in 12 French hospitals, we reported that 26.9% (14/52) of the amoxicillin-clavulanate-resistant Proteus mirabilis isolates produced the OXA-23 carbapenemase. We found that an inhibition zone diameter of <11 mm around the amoxicillin-clavulanate disc was an accurate screening cutoff to detect these OXA-23 producers. We confirmed by whole-genome sequencing that these OXA-23-producers all belonged to the same lineage that has been demonstrated to disseminate OXA-23 or OXA-58 in P. mirabilis.