The Cuprizone Model: Dos and Do Nots
Jiangshan Zhan, Teresa Mann, Sarah Joost, Newshan Behrangi, Marcus Frank, Markus Kipp
Abstract
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options. During the last decade, the model of toxic demyelination induced by cuprizone has become more and more popular, and it has contributed substantially to our understanding of distinct yet important aspects of the MS pathology. Here, we aim to provide a practical guide on how to use the cuprizone model and which pitfalls should be avoided.
Topics & Concepts
Multiple sclerosisNeuroscienceDiseaseMedicinePathogenesisCentral nervous systemDemyelinating diseasePathologyPsychologyImmunologyMultiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanismsPeripheral Neuropathies and Disorders