lncRNA-SNHG17 promotes colon adenocarcinoma progression and serves as a sponge for miR-375 to regulate CBX3 expression.
Jia Liu, Yang Zhan, Jiefu Wang, Junfeng Wang, Jiansheng Guo, Dalu Kong
Abstract
. Further investigations showed SNHG17 serves as competing endogenous RNA (ceRNA) for miR-375 to regulate CBX3 expression. Additionally, we showed the roles of SNHG17 on COAD cell behaviors were exerted via miR-375/CBX3 axis. In conclusion, we demonstrated a novel SNHG17/miR-375/CBX3 triplets that participates in COAD progression, which may provide promising therapeutic targets for COAD.
Topics & Concepts
Competing endogenous RNAmicroRNABiologyRNACarcinogenesisLong non-coding RNACancer researchMolecular biologyGene expressionGeneCell biologyGeneticsCancer-related molecular mechanisms researchRNA Research and SplicingCircular RNAs in diseases