Divergent synthesis of 3-formylpyrazolo[1,5- <i>a</i> ]pyrimidines and methylene-bridged bis(pyrazolo[1,5- <i>a</i> ]pyrimidines) using DMSO as a single carbon synthon
Papiya Sikdar, Sourav Das, Sheetal Saini, Sanghapal D. Sawant, Avik Kumar Bagdi
Abstract
A chemodivergent approach has been developed for the synthesis of 3-formylpyrazolo[1,5- a ]pyrimidines and methylene-bridged bis(pyrazolo[1,5- a ]pyrimidines) employing safe and inexpensive DMSO as a C1 synthon and persulfate as an oxidant.
Topics & Concepts
SynthonMethyleneChemistryStereochemistryCombinatorial chemistryMedicinal chemistrySynthesis and Biological EvaluationSynthesis and Reactivity of HeterocyclesSynthesis of heterocyclic compounds