Cobalt(II)-Catalyzed Intermolecular Aminocarbonylation of Indoles with Amines
Ping Wei, Jun Ying, Xiao‐Feng Wu
Abstract
A cobalt(II)-catalyzed C2–H carbonylation of indoles with amines toward indole-2-carboxamides has been developed. By employing Co(OAc) 2 ·4H 2 O as an inexpensive catalyst and using benzene-1,3,5-triyl triformate (TFBen) as the CO surrogate, a variety of indole-2-carboxamide derivatives were produced in moderate to high yields. Additionally, several bioactive-molecule-related compounds can be applied as substrates, as well.
Topics & Concepts
ChemistryIndole testCatalysisCobaltIntermolecular forceCarbonylationBenzeneCombinatorial chemistryMoleculeMedicinal chemistryOrganic chemistryCarbon monoxideCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis