Ranolazine rescues the heart failure phenotype of PLN-deficient human pluripotent stem cell-derived cardiomyocytes
Youxu Jiang, Xiaowei Li, Tianwei Guo, Wenjing Lu, Shuhong Ma, Yun Chang, Yuanxiu Song, Siyao Zhang, Rui Bai, Hongyue Wang, Man Qi, Hongfeng Jiang, Hongjia Zhang, Feng Lan
Abstract
transport and the imbalance of cellular energy metabolism are the primary mechanisms for PLN deficiency pathogenesis.
Topics & Concepts
ContractilityBiologyInduced pluripotent stem cellPhospholambanKnockout mouseRanolazineCell biologyHeart failurePhenotypeEndoplasmic reticulumInternal medicineEndocrinologyPharmacologyGeneticsMedicineEmbryonic stem cellGeneCardiac electrophysiology and arrhythmiasCardiomyopathy and Myosin StudiesCardiac pacing and defibrillation studies