Parabiosis modeling: protocol, application and perspectives
Cui Yang, 中国电子科技大学四川省人民医院神经病学研究所，四川 成都610072，中国, Zhilan Liu, Jun Wang, Xian‐Le Bu, Yan‐Jiang Wang, Yang Xiang, 中国科学院四川转化医学研究医院，四川 成都610072，中国, 西部战区总医院神经内科，四川 成都 610083，中国, 陆军军医大学大坪医院神经内科和临床神经科学中心，重庆400012，中国, 中国电子科技大学四川省人民医院神经内科，四川 成都610072，中国
Abstract
Parabiosis is a surgical method of animal modeling with a long history. It has been widely used in medical research, particularly in the fields of aging, stem cells, neuroscience, and immunity in the past two decades. The protocols for parabiosis have been improved many times and are now widely accepted. However, researchers need to consider many details, from surgical operation to perioperative management, to reduce mortality and maintain the parabiosis union. Although parabiosis has certain inevitable limitations, it still has broad application prospects as an irreplaceable animal model in the medical research field.