An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data
Tamar Mehlman, Helen M. Ginn, D.A. Keedy
Topics & Concepts
Allosteric regulationFragment (logic)AffinitiesLigand (biochemistry)Drug discoveryComputational biologySmall moleculeBinding siteAllosteric enzymeProtein structurePlasma protein bindingChemistryEnzymeBiologyStereochemistryComputer scienceBiochemistryAlgorithmReceptorProtein Tyrosine PhosphatasesEnzyme Structure and FunctionBiochemical and Molecular Research