Synthesis of quinazoline by decarboxylation of 2-aminobenzylamine and α-keto acid under visible light catalysis
Jiangnan Yang, Zongbo Xie, Liang Jin, Xuehua Chen, Zhanggao Le
Abstract
Quinazoline compounds demonstrate a variety of physiological and pharmacological activities. However, the most common syntheses require large quantities of oxidants, high temperature, and other extreme conditions. In this study, quinazoline compounds were synthesized from the condensation of α-keto acid and 2-aminobenzylamine and then decarboxylation under blue LED irradiation at room temperature without transition metal catalysts or additives. Therefore, we demonstrated that by using α-keto acid as the acyl source, decarboxylation can be realized under blue LED without oxidants, in a simple, mild, and environmentally friendly process.
Topics & Concepts
DecarboxylationChemistryCatalysisQuinazolineCondensationOrganic chemistryMetalCombinatorial chemistryThermodynamicsPhysicsQuinazolinone synthesis and applicationsRadical Photochemical ReactionsPhenothiazines and Benzothiazines Synthesis and Activities