S<sub>N</sub>2 versus S<sub>N</sub>2′ Competition
Thomas Hansen, Pascal Vermeeren, Lea de Jong, F. Matthias Bickelhaupt, Trevor A. Hamlin
Abstract
2' competition and, again, demonstrate that the concepts of a reaction's "characteristic distortivity" and "transition state acidity" provide explanations and design tools for understanding and predicting reactivity trends in organic synthesis.
Topics & Concepts
SN2 reactionAllylic rearrangementNucleophileChemistryDensity functional theoryCompetition (biology)Reactivity (psychology)Leaving groupSubstitution reactionNucleophilic substitutionStereochemistryComputational chemistryMedicinal chemistryOrganic chemistryCatalysisEcologyBiologyMedicinePathologyAlternative medicineChemical Reaction MechanismsAdvanced Chemical Physics StudiesOrganic Chemistry Cycloaddition Reactions