Design and chemical behavior of novel pyrimidine derivatives and their evaluation of cytotoxicity
Alaa R. Sakr, Mohamed G. Assy, Youssra S. ELasaad
Abstract
Diphenyl-4-thioxo-1,4-dihydropyrimidin-5-yl)ethan-1-one 4 was obtained upon the reaction of (phenylamino)but-2-enethioyl)benzamide 3 with sodium hydroxide. The reactions of 4 with several active species such as benzaldehyde, urea, malononitrile, ethyl cyanoacetate, hydrazine, and carbon disulfide were studied. The antitumor activities of some selective compounds were examined against two cell lines: Mammalian cell lines: A-549 cells (human lung cancer cell line) and MRC-5 cells (normal human lung fibroblast cell line); some of the compounds were highly efficient; compound 13 has the most effective anticancer activity.
Topics & Concepts
MalononitrileChemistryCytotoxicityEthyl cyanoacetateCell cultureBenzamideCarbon disulfideHydrazine (antidepressant)PyrimidineSodium hydroxideBenzaldehydeUreaCombinatorial chemistryOrganic chemistryStereochemistryBiochemistryIn vitroCatalysisBiologyGeneticsQuinazolinone synthesis and applicationsSynthesis and biological activityMulticomponent Synthesis of Heterocycles