Arsenic trioxide sensitizes pancreatic cancer cells to gemcitabine through downregulation of the TIMP1/PI3K/AKT/mTOR axis
Zhenfeng Tian, Ying Tan, Xingyi Lin, Mingxin Su, Lele Pan, Lijun Lin, Guangsheng Ou, Yinting Chen
Topics & Concepts
PI3K/AKT/mTOR pathwayTIMP1Cancer researchProtein kinase BGemcitabineChemistryArsenic trioxideEpithelial–mesenchymal transitionEverolimusMedicineApoptosisMetastasisPharmacologyCancerOncologyInternal medicineBiochemistryGene expressionGeneRetinoids in leukemia and cellular processesAcute Myeloid Leukemia ResearchPancreatic and Hepatic Oncology Research