Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model
Ting Xiong, Valentina Rodriguez Paris, Melissa C Edwards, Ying Hu, Blake J. Cochran, Kerry‐Anne Rye, William L. Ledger, Vasantha Padmanabhan, David J. Handelsman, Robert B. Gilchrist, Kirsty A. Walters
Abstract
Hyperandrogenism is a key feature in the pathogenesis of polycystic ovary syndrome (PCOS); however, the tissue sites of androgen receptor (AR) signaling are unclear. In this study, AR signaling in white and brown adipose tissue, but less likely in skeletal muscle, was found to be involved in the development of metabolic PCOS traits, highlighting the importance of androgen actions in adipose tissue and obesity in the manifestation of metabolic disturbances.
Topics & Concepts
Adipose tissuePolycystic ovaryHyperandrogenismEndocrinologyAndrogen receptorInternal medicineSkeletal muscleAndrogenWhite adipose tissueBiologyMetabolic syndromeObesityMedicineInsulin resistanceHormoneProstate cancerCancerOvarian function and disordersReproductive Biology and FertilityHair Growth and Disorders