Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
Han Liu, Yujie Hong, Hui Chen, Xianggui Wang, Jiale Dong, Xiaoqian Li, Zihan Shi, Qian Zhao, Longyuan Zhou, Jiaxin Wang, Qiuling Zeng, Qinglin Tang, Qi Liu, Florian Rieder, Baili Chen, Minhu Chen, Rui Wang, Yao Zhang, Ren Mao, Xianxing Jiang
Abstract
histone lactylation. Simultaneously activating GCGR/GLP1R with the novel dual agonist peptide 1907B holds promise as a treatment strategy for alleviating intestinal fibrosis.
Topics & Concepts
ChemistryCell biologyHistoneSignal transductionDual roleDual (grammatical number)Cancer researchFibrosisMedicineInternal medicineBiochemistryBiologyGeneArtCombinatorial chemistryLiteratureDigestive system and related healthPancreatic and Hepatic Oncology ResearchEpigenetics and DNA Methylation