Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma
Kaile Yue, Dashuang Sheng, Xinxin Xue, Lanlan Zhao, Guoping Zhao, Chuandi Jin, Lei Zhang
Abstract
The burgeoning field of oncobiome research declared that members of the intratumoral microbiome besides Helicobacter pylori existed in tumor tissues and participated in the occurrence and development of gastric cancer, and the methylation of host DNA may be a potential target of microbes and their metabolites. Current research focuses mostly on species composition, but the functional genes of the members of the microbiota are also key to their interaction with the host.
Topics & Concepts
MicrobiomeDNA methylationAdenocarcinomaMethylationEsophageal adenocarcinomaMediationBiologyHost (biology)StomachGeneticsCancer researchOncologyDNAMedicineInternal medicineGeneCancerGene expressionSociologySocial scienceEpigenetics and DNA MethylationFerroptosis and cancer prognosisGut microbiota and health