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Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors

Heba S. Mohamed, Noha H. Amin, Mohammed T. El‐Saadi, Hamdy M. Abdel‐Rahman

2022Bioorganic Chemistry33 citationsDOI

Topics & Concepts

ChemistryTubulinPyrimidineCombretastatinStereochemistryDocking (animal)Cell cycleMicrotubuleMicrotubule polymerizationIC50PolymerizationApoptosisColchicineCell cycle checkpointIn vitroBiochemistryCell biologyBiologyOrganic chemistryMedicinePolymerGeneticsNursingSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic Compounds
Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors | Litcius