Force-mediated molecule release from double network hydrogels
Pavithra Bhakthi Jayathilaka, Thomas G. Molley, Yuwan Huang, Md Shariful Islam, Michael Buche, Meredith N. Silberstein, Jamie J. Kruzic, K. Kilian
Abstract
The incorporation of mechanosensitive linkages into polymers has led to materials with dynamic force responsivity. Here we report oxanorbornadiene cross-linked double network hydrogels that release molecules through a force-mediated retro Diels-Alder reaction. The molecular design and tough double network of polyacrylamide and alginate promote significantly higher activation at substantially less force than pure polymer systems. Activation at physiologically relevant forces provides scope for instilling dynamic mechanochemical behavior in soft biological materials.
Topics & Concepts
Self-healing hydrogelsMoleculeChemistryMaterials scienceChemical engineeringBiophysicsNanotechnologyPolymer chemistryOrganic chemistryEngineeringBiologyForce Microscopy Techniques and ApplicationsMechanical and Optical ResonatorsHydrogels: synthesis, properties, applications