Recent Advances in the Synthesis of Thiazole Ring: Mini Review
Asmaa E. Kassab, Inas G. Shahin, Khaled O. Mohamed, Azza T. Taher, Abdelrahman S. Mayhoub
Abstract
Abstract: The thiazole scaffold is an essential structural foundation in a plethora of pharmaceutical products having an extensive array of biological activities. Consequently, its synthesis has been extensively discussed in the literature. In this mini review, we have summarized the recent advances in thiazole synthesis, covering articles published between 2002 and 2021. We have reviewed and discussed various recent and novel routes for synthesizing compounds containing thiazole rings from various starting materials such as thiourea, thioamide, or thiosemicarbazone. Additionally, we have illustrated environmentally benign methods for thiazole synthesis. We hope that this review can help other researchers efficiently synthesize the thiazole ring.