Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo
Aref Shahini, Nika Rajabian, Debanik Choudhury, Shahryar Shahini, Kalyan Vydiam, T M Nguyen, Joseph Kulczyk, Tyler Santarelli, Izuagie Ikhapoh, Yali Zhang, Jianmin Wang, Song Liu, Aimee Stablewski, Ramkumar Thiyagarajan, Kenneth L. Seldeen, Bruce R. Troen, Jennifer J. Peirick, Pedro Lei, Stelios T. Andreadis
Abstract
myofibers. This work demonstrates the feasibility of reversing the effects of cellular senescence in vitro and in vivo, with no need for reprogramming to the pluripotent state.
Topics & Concepts
Skeletal muscleHomeobox protein NANOGSenescenceIn vivoCell biologyProgenitor cellBiologyEmbryonic stem cellIn vitroStem cellAnatomyInduced pluripotent stem cellGeneticsGeneTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders