Novel 6-amino-1,3,5-triazine derivatives as potent BTK inhibitors: structure-activity relationship (SAR) analysis and preliminary mechanism investigation
Maoxu Xiao, Meiqi Zhu, Shuangjie Wu, Luyu Ma, Lin Qi, Si Ha, Shuangshuang Xiong, Mingqi Chen, Deying Chen, Guoshun Luo, Hua Xiang
Topics & Concepts
Bruton's tyrosine kinaseChemistryTyrosine kinaseRaji cellIbrutinibStructure–activity relationshipKinaseBiochemistryCancer researchPharmacologyBiophysicsCellSignal transductionIn vitroBiologyLeukemiaImmunologyChronic lymphocytic leukemiaChronic Lymphocytic Leukemia ResearchChronic Myeloid Leukemia TreatmentsMonoclonal and Polyclonal Antibodies Research