Schwarzinicines A–G, 1,4-Diarylbutanoid–Phenethylamine Conjugates from the Leaves of <i>Ficus schwarzii</i>
Premanand Krishnan, Fong‐Kai Lee, Veronica Alicia Yap, Yun‐Yee Low, Toh‐Seok Kam, Kien‐Thai Yong, Kang‐Nee Ting, Kuan‐Hon Lim
Abstract
Schwarzinicines A–G (1–7), representing the first examples of 1,4-diarylbutanoid–phenethylamine conjugates, were isolated from the leaves of Ficus schwarzii. The structures of these compounds were determined by detailed analysis of their MS, 1D and 2D NMR data. Compounds 1–4 exhibited pronounced vasorelaxant effects in the rat isolated aorta (Emax 106–120%; EC50 0.96–2.10 μM). However, compounds 1 and 2 showed no cytotoxic effects against A549, MCF-7, and HCT 116 human cancer cells (IC50 > 10 μM).
Topics & Concepts
PhenethylamineFicusStereochemistryConjugatePharmacognosyEC50ChemistryTraditional medicineBiological activityBiologyIn vitroBotanyBiochemistryMedicineMathematical analysisMathematicsPhytochemistry and biological activities of Ficus speciesPhytochemistry and Bioactive CompoundsPhytochemistry and Biological Activities