VGH-TAYLOR: Comprehensive Precision Medicine Study Protocol on the Heterogeneity of Taiwanese Breast Cancer Patients
Chunyu Liu, Chi‐Cheng Huang, Yi‐Fang Tsai, Ta‐Chung Chao, Pei‐Ju Lien, Yen‐Shu Lin, Chin-Jung Feng, Ji‐Lin Chen, Yen-Jen Chen, Jen‐Hwey Chiu, Chih‐Yi Hsu, Ling‐Ming Tseng
Abstract
Heterogeneity in breast cancer leads to diverse morphological features and different clinical outcomes. There are inherent differences in breast cancer between the populations in Asia and in western countries. The use of immune-based treatment in breast cancer is currently in the developmental stage. The VGH-TAYLOR study is designed to understand the genetic profiling of different subtypes of breast cancer in Taiwan and define the molecular risk factors for breast cancer recurrence. The T-cell receptor repertoire and the potential effects of immunotherapy in breast cancer subjects is evaluated. The favorable biomarkers for early detection of tumor recurrence, diagnosis and prognosis may provide clues for the selection of individualized treatment regimens and improvement in breast cancer therapy.