Fe-BPsalan complex-catalyzed asymmetric 1,3-dipolar [3 + 2] cycloaddition reaction of <i>N</i>,<i>N</i>′-cyclic azomethine imines with α,β-unsaturated acyl imidazoles
Lu Hao, Kai-Ge Chen, Gongxin Li, Kun Zhan, Haoyang Wang, Zhen‐Jiang Xu, Chi‐Ming Che
Abstract
A practical iron-catalyzed asymmetric 1,3-dipolar cycloaddition of N , N ′-cyclic azomethine imines with α,β-unsaturated acyl imidazoles was developed to afford N , N ′-bicyclic pyrazolidine in good yields and excellent stereoselectivities (up to 98% ee).
Topics & Concepts
ChemistryCycloadditionAzomethine ylideCatalysis1,3-Dipolar cycloadditionMedicinal chemistryBicyclic moleculeOrganic chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms