Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties
Joanna Stefaniak, Michał G. Nowak, Marek Wojciechowski, Sławomir Milewski, Andrzej S. Skwarecki
Abstract
-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating microbial cell membranes, has been improved using the pro-drug approach. On the other hand, a number of heterocyclic and polycyclic compounds demonstrating antimicrobial activity have been presented as putative inhibitors of the enzyme, based on the results of molecular docking to GlcN-6-P synthase matrix. The most active compounds of this group could be considered promising leads for development of novel antimicrobial drugs or antidiabetics, provided their selective toxicity is confirmed.
Topics & Concepts
AntimicrobialChemistryGlucosamineEnzymeBiochemistryATP synthaseDocking (animal)Active sitePhosphateOrganic chemistryMedicineNursingCarbohydrate Chemistry and SynthesisBiochemical and Molecular ResearchGlycosylation and Glycoproteins Research