Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
Rachel M. Woodhouse, Natalya Frolows, Guoqiang Wang, Azelle Hawdon, Edmund Heng Kin Wong, Linda C. Dansereau, Yingying Su, Liam D. Adair, Elizabeth J. New, Ashleigh M. Philp, Wei Kang Tan, Andrew Philp, Alyson Ashe
Abstract
mutant animals suggest an imbalance in metabolites may underlie the fertility defect. Our results demonstrate a role for SDHA-2 in sperm motility and male reproductive health and establish an animal model of SDH deficiency-associated infertility.
Topics & Concepts
SpermSperm motilityFertilityMotilitySuccinate dehydrogenaseFunction (biology)MitochondrionCell biologyMale fertilityChemistryAndrologyBiologyMedicineEnvironmental healthPopulationMitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsAdipose Tissue and Metabolism