Synthesis, molecular modelling and QSAR study of new <i>N-</i> phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity
Mona F. Said, Riham F. George, Andrea Petreni, Claudiu T. Supuran, Nada M. Mohamed
Abstract
CA I, II, IX and XII isoforms.
Topics & Concepts
Carbonic anhydraseChemistryIsatinCytotoxicityAcetazolamideStereochemistryCarbonic anhydrase IIDocking (animal)EnzymeCarbonic Anhydrase IIndole testBiochemistryGene isoformIn vitroOrganic chemistryBiologyGeneMedicinePhysiologyNursingEnzyme function and inhibitionSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases