Inhibition of the cGAS–STING pathway <i>via</i> an endogenous copper ion-responsive covalent organic framework nanozyme for Alzheimer's disease treatment
Haochen Zhang, Junlin Ya, Mengyu Sun, Xiubo Du, Jinsong Ren, Xiaogang Qu
Abstract
studies demonstrate that TP@PB-COF@NADH with NIR-II irradiation significantly improves cognitive function in 3× Tg-AD mice, with a reduction in amyloid-β (Aβ) plaque, neuroinflammation and neuronal damage. Collectively, this work presents a promising approach for AD treatment by using an AD brain harmful excess endogenous copper ion-responsive and efficient nanozyme.
Topics & Concepts
StingInnate immune systemDiseaseEndogenyAlzheimer's diseaseCovalent bondChemistryImmune systemCell biologyBiologyMedicineImmunologyBiochemistryInternal medicineOrganic chemistryEngineeringAerospace engineeringMosquito-borne diseases and controlNanoplatforms for cancer theranosticsinterferon and immune responses