Decomposable STING nanoagonist-amplified oncolytic virotherapy through remodeling the immunosuppressive microenvironment of triple-negative breast cancer
Min Mu, Guoqing Wang, Bo Chen, Hui Li, Chenqian Feng, Rangrang Fan, Nianyong Chen, Bo Han, Aiping Tong, Bingwen Zou, Gang Guo
Abstract
T cells and maturation dendritic cells (DCs) due to the synergetic effect of the STING pathway and OVs, thereby activating the immune response, resulting in the significant inhibition of TNBC growth. This work highlights the potential of the STING agonist in enhancing the antitumor efficacy of OVs and provides a potent platform for TNBC therapy.
Topics & Concepts
Oncolytic virusTriple-negative breast cancerCancer researchTumor microenvironmentStingBreast cancerMedicineVirotherapyCancerInternal medicineTumor cellsPhysicsThermodynamicsVirus-based gene therapy researchinterferon and immune responsesBacteriophages and microbial interactions