Deubiquitinase USP13 regulates glycolytic reprogramming and progression in osteosarcoma by stabilizing METTL3/m<sup>6</sup>A/ATG5 axis
Ce Wang, Yichen Meng, Jianquan Zhao, Jun Ma, Yuechao Zhao, Rui Gao, Wei Liu, Xuhui Zhou
Abstract
. Collectively, our study results indicate that USP13 promotes glycolysis and tumor progression in OS by stabilizing METTL3, thereby stabilizing ATG5 mRNA and facilitating autophagy in OS. Our findings demonstrate the role of the USP13-METTL3-ATG5 cascade in OS progression and show that USP13 is a crucial DUB for the stabilization of METTL3 and a promising therapeutic target for treating OS.
Topics & Concepts
ReprogrammingATG5UbiquitinDeubiquitinating enzymeCancer researchCell biologyAutophagyBiologyGlycolysisGeneEnzymeBiochemistryApoptosisRNA modifications and cancerUbiquitin and proteasome pathwaysBiochemical and Molecular Research