Autophagy as a Vital Therapy Target for Renal Cell Carcinoma
Yinghua He, Guo Tian
Abstract
Autophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC). Many autophagy-related proteins are regarded as prognostic markers of RCC. Researchers have attempted to explore synthetic and phytochemical drugs for RCC therapy that target autophagy. In this review, we highlight the importance of autophagy in RCC and potential treatments related to autophagy.
Topics & Concepts
AutophagyRenal cell carcinomaOrganelleCancer researchDual roleULK1MedicineCellBiologyCell biologyBioinformaticsChemistryPathologyBiochemistryApoptosisPhosphorylationAMPKProtein kinase ACombinatorial chemistryAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseSirtuins and Resveratrol in Medicine