Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity
Junyu Xu, Hongmei Li, Xinren Wang, Jianhang Huang, Shuwen Li, Chenhe Liu, Ruinan Dong, Gaoyuan Zhu, Chunqi Duan, Fei Jiang, Yanmin Zhang, Yuqin Zhu, Tianyi Zhang, Yadong Chen, Weifang Tang, Tao Lu
Topics & Concepts
ChemistryCoumarinCyclin-dependent kinaseSelectivityhERGBromodomainStereochemistryPharmacologyBiochemistryBiophysicsApoptosisCell cycleAcetylationPotassium channelMedicineGeneBiologyCatalysisOrganic chemistryCancer-related Molecular PathwaysAcute Myeloid Leukemia ResearchProtein Degradation and Inhibitors