Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis
Panpan Wei, Jia-Cheng Ji, Xujun Ma, Zheng-Hui Li, Hong‐Lian Ai, Xinxiang Lei, Ji‐Kai Liu
Abstract
Abstract Three new pyrrole alkaloids albifipyrrols A–C ( 1–3 ), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activity. Fortunately, compound 2 exhibits certain inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC 50 value 16.16 μM. Graphical Abstract
Topics & Concepts
Plant biochemistryPyrroleFungusAlkaloidStereochemistryChemistryBiologyBotanyBiochemistryOrganic chemistryGeneMicrobial Natural Products and BiosynthesisCancer therapeutics and mechanismsFungal Biology and Applications