Improvement of tacrolimus production in Streptomyces tsukubaensis by mutagenesis and optimization of fermentation medium using Plackett–Burman design combined with response surface methodology
Ling-bin Yan, Zhu-lan Zhang, Yin Zhang, Huang-jian Yang, Guanrong Qiu, De‐Shen Wang, Yun-Yang Lian
Topics & Concepts
FermentationResponse surface methodologyPlackett–Burman designIndustrial fermentationStarchCentral composite designMutagenesisChemistryFood scienceStrain (injury)StreptomycesChromatographyBiochemistryBiologyBacteriaMutationGeneticsAnatomyGeneMicrobial Natural Products and BiosynthesisBacterial Genetics and BiotechnologyBiopolymer Synthesis and Applications