Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy
Sheng‐Li Ming, Shuang Zhang, Qi Wang, Lei Zeng, Lu‐Yu Zhou, Meng-Di Wang, Ying‐Xian Ma, Liqiang Han, Kai Zhong, Zhu He-shui, Yilin Bai, Guo‐Yu Yang, Jiang Wang, Bei‐Bei Chu
Abstract
: tissue culture infective dose; UB: ubiquitin; UBA: ubiquitin-associated domain; UBL: ubiquitin-like domain; UL9: DNA replication origin-binding helicase; UPR: unfolded protein response; USPs: ubiquitin-specific proteases; VHS: virion host shutoff; VP16: viral protein 16; XBP1: X-box binding protein 1; XBP1s: small XBP1; XBP1(t): XBP1-total.
Topics & Concepts
BiologyAutophagyCell biologyVirologyStress granuleApoptosisBiochemistryTranslation (biology)Messenger RNAGeneAutophagy in Disease and TherapyToxoplasma gondii Research StudiesEndoplasmic Reticulum Stress and Disease