A dual-modal ROS generator based on multifunctional PDA–MnO<sub>2</sub>@Ce6 nanozymes for synergistic chemo-photodynamic antibacterial therapy
Anni Cui, Ying Bao, Haitao Xu, Xin Mu, Xiahua Zhong, Wynn Wee, Fanqi Wu, Guiye Shan
Abstract
PMCL nanozymes catalyze endogenous H 2 O 2 to achieve O 2 self-supplied PDT and improve the •OH generation by photothermal effect. Based on dual-enzyme activities, PMCL exhibits powerful antibacterial efficacy and mature bacterial biofilm eradication.
Topics & Concepts
Singlet oxygenPhotodynamic therapyReactive oxygen speciesHydrogen peroxideChemistryAntibacterial activityCatalaseBacteriaBiofilmPhotothermal therapyRadicalBiofoulingCombinatorial chemistryNanotechnologyMembraneMaterials scienceOxygenBiochemistryOxidative stressBiologyOrganic chemistryGeneticsNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisAdvanced Photocatalysis Techniques