Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19
Mahdi Eskandarian Boroujeni, Leila Simani, Hans A.R. Bluyssen, Hamid Reza Samadikhah, Soheila Zamanlui Benisi, Sanaz Hassani, Nader Akbari Dilmaghani, Mobina Fathi, Kimia Vakili, Gholam-Reza Mahmoudiasl, Hojjat‐Allah Abbaszadeh, Meysam Hassani Moghaddam, Mohammad‐Amin Abdollahifar, Abbas Aliaghaei
Abstract
The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected people worldwide. A growing body of literature suggests the neurological complications and manifestations in response to COVID-19 infection. Herein, we explored the inflammatory and immune responses in the post-mortem cerebral cortex of patients with severe COVID-19. The participants comprised three patients diagnosed with severe COVID-19 from March 26, 2020, to April 17, 2020, and three control patients. Our findings demonstrated a surge in the number of reactive astrocytes and activated microglia, as well as low levels of glutathione along with the upregulation of inflammation- and immune-related genes IL1B, IL6, IFITM, MX1, and OAS2 in the COVID-19 group. Overall, the data imply that oxidative stress may invoke a glial-mediated neuroinflammation, which ultimately leads to neuronal cell death in the cerebral cortex of COVID-19 patients.